| 5. Round | 29/01/2022 | Alebrijes de Oaxaca | - | Atlético Morelia | 1:1 |  |
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| 6. Round | 01/02/2022 | Tepatitlán | - | Alebrijes de Oaxaca | 1:2 | ||||
| 7. Round | 09/02/2022 | Alebrijes de Oaxaca | - | Venados FC | 1:0 | |
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| 8. Round | 17/02/2022 | Cimarrones de Sonora | - | Alebrijes de Oaxaca | 0:1 | |
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| 9. Round | 22/02/2022 | Mineros de Zacatecas | - | Alebrijes de Oaxaca | 4:2 |  |
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| 12. Round | 16/03/2022 | Alebrijes de Oaxaca | - | Coyotes de Tlaxcala | 2:1 | |
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| 13. Round | 22/03/2022 | Tapatío | - | Alebrijes de Oaxaca | 0:1 | |
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| 14. Round | 27/03/2022 | Alebrijes de Oaxaca | - | Dorados de Sinaloa | 5:1 |
Mexico