| 1. Round | 21/07/2019 | Santos Laguna [U20] | - | Deportivo Guadalajara [U20] | 0:2 | ||||
| 7. Round | 28/08/2019 | Club León [U20] | - | Santos Laguna [U20] | 1:2 |  |
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| 2. Round | 06/09/2019 | Santos Laguna [U20] | - | FC Juárez [U20] | 2:0 |  |
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| 9. Round | 15/09/2019 | Santos Laguna [U20] | - | CF Pachuca [U20] | 2:0 | |
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| 10. Round | 21/09/2019 | Atlético San Luis [U20] | - | Santos Laguna [U20] | 1:5 | |
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| 11. Round | 25/09/2019 | Santos Laguna [U20] | - | CD Veracruz [U20] | 2:0 | ||||
| 12. Round | 29/09/2019 | Pumas UNAM [U20] | - | Santos Laguna [U20] | 2:1 | ||||
| 3. Round | 10/10/2019 | Atlas Guadalajara [U20] | - | Santos Laguna [U20] | 3:0 | ||||
| 14. Round | 18/10/2019 | Santos Laguna [U20] | - | Club Tijuana [U20] | 2:0 | ||||
| 15. Round | 25/10/2019 | Monarcas Morelia [U20] | - | Santos Laguna [U20] | 1:0 | ||||
| 17. Round | 02/11/2019 | CF América [U20] | - | Santos Laguna [U20] | 1:2 | |
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| 18. Round | 10/11/2019 | Santos Laguna [U20] | - | Cruz Azul [U20] | 1:0 | |
Mexico