| 1. Round | 15/01/2022 | Mazorqueros | - | Colima FC | 3:2 | ||||
| 3. Round | 30/01/2022 | Colima FC | - | Correcaminos UAT II | 1:0 | ||||
| 4. Round | 05/02/2022 | Leones Negros II | - | Colima FC | 1:2 |  |
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| 7. Round | 27/02/2022 | Colima FC | - | Tuzos de la UAZ | 1:1 | ||||
| 8. Round | 05/03/2022 | Alacranes de Durango | - | Colima FC | 6:1 | ||||
| 9. Round | 13/03/2022 | Colima FC | - | Cimarrones de Sonora II | 0:1 | ||||
| 10. Round | 19/03/2022 | Saltillo FC | - | Colima FC | 2:1 | ||||
| 2. Round | 24/03/2022 | Colima FC | - | Tecos Fútbol Club | 0:1 | ||||
| 11. Round | 26/03/2022 | Colima FC | - | Tritones Vallarta | 0:2 | ||||
| 12. Round | 02/04/2022 | Catedráticos Elite | - | Colima FC | 3:3 |  |
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| 13. Round | 09/04/2022 | Colima FC | - | Gavilanes de Matamoros | 0:0 |
Colombia