| 1. Round | 16/05/2021 | Deportivo Maldonado | - | Liverpool | 2:4 | ||||
| 2. Round | 24/05/2021 | River Plate | - | Liverpool | 3:2 | ||||
| 7. Round | 22/06/2021 | Liverpool | - | Fénix | 5:2 | ||||
| 8. Round | 27/06/2021 | Boston River | - | Liverpool | 1:1 | ||||
| 9. Round | 06/07/2021 | Liverpool | - | Montevideo Wanderers | 2:1 | ||||
| 10. Round | 12/07/2021 | Rentistas | - | Liverpool | 2:1 | ||||
| 11. Round | 25/07/2021 | Liverpool | - | Peñarol | 3:3 |  |
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| 12. Round | 01/08/2021 | Montevideo City Torque | - | Liverpool | 0:3 | ||||
| 13. Round | 08/08/2021 | Liverpool | - | Villa Española | 2:2 | ||||
| 14. Round | 15/08/2021 | Nacional | - | Liverpool | 1:0 | ||||
| 15. Round | 21/08/2021 | Liverpool | - | Cerrito | 3:0 |
Uruguay
Italy