| 2. Round | 25/09/2021 | Cafetaleros de Chiapas | - | Inter Playa | 3:2 | ||||
| 3. Round | 01/10/2021 | Inter Playa | - | Lobos ULMX | 3:1 | ||||
| 4. Round | 08/10/2021 | CD Zap | - | Inter Playa | 1:5 | ||||
| 5. Round | 13/10/2021 | Inter Playa | - | Reboceros de La Piedad | 1:1 | ||||
| 7. Round | 22/10/2021 | Inter Playa | - | Deportivo Dongu | 1:0 |  |
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| 8. Round | 31/10/2021 | Montañeses FC | - | Inter Playa | 1:1 | ||||
| 13. Round | 27/11/2021 | Escorpiones | - | Inter Playa | 0:5 |
Mexico