| 18. Round | 02/07/2022 | Deportes Iquique | - | Santiago Wanderers | 2:1 | ||||
| 20. Round | 15/07/2022 | Santiago Morning | - | Santiago Wanderers | 1:2 |  |
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| 21. Round | 25/07/2022 | Santiago Wanderers | - | San Luis | 1:2 | ||||
| 22. Round | 02/08/2022 | Rangers | - | Santiago Wanderers | 1:2 | |
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| 23. Round | 07/08/2022 | Santiago Wanderers | - | Fernández Vial | 2:2 | ||||
| 24. Round | 12/08/2022 | CD Magallanes | - | Santiago Wanderers | 0:1 | ||||
| 19. Round | 16/08/2022 | Santiago Wanderers | - | Deportes Temuco | 3:0 | ||||
| 25. Round | 21/08/2022 | Santiago Wanderers | - | Deportes Copiapó | 1:0 | ||||
| 26. Round | 28/08/2022 | Puerto Montt | - | Santiago Wanderers | 1:1 |  |
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| 29. Round | 25/09/2022 | Santiago Wanderers | - | Recoleta | 0:0 | ||||
| 30. Round | 03/10/2022 | Barnechea | - | Santiago Wanderers | 1:0 | ||||
| 31. Round | 09/10/2022 | Santiago Wanderers | - | Cobreloa | 2:2 | |
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| 32. Round | 15/10/2022 | Universidad de Concepción | - | Santiago Wanderers | 1:1 | |
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| 34. Round | 02/11/2022 | Santiago Wanderers | - | Santa Cruz | 2:0 |
Chile