| 1. Round | 26/07/2015 | Santos Laguna | - | Club León | 1:3 | ||||
| 2. Round | 02/08/2015 | Chiapas FC | - | Santos Laguna | 2:1 | ||||
| 4. Round | 12/08/2015 | Gallos Blancos | - | Santos Laguna | 1:2 | ||||
| 6. Round | 23/08/2015 | CF Monterrey | - | Santos Laguna | 1:1 | ||||
| 8. Round | 13/09/2015 | Puebla FC | - | Santos Laguna | 0:1 | ||||
| 14. Round | 24/10/2015 | Santos Laguna | - | Cruz Azul | 1:2 |
Mexico