| 1. Round | 23/07/2018 | Santos Laguna | - | Lobos BUAP | 2:1 | ||||
| 2. Round | 28/07/2018 | Monarcas Morelia | - | Santos Laguna | 3:1 | ||||
| 3. Round | 06/08/2018 | Santos Laguna | - | Puebla FC | 2:0 |  |
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| 4. Round | 13/08/2018 | Deportivo Guadalajara | - | Santos Laguna | 1:2 | ||||
| 9. Round | 16/09/2018 | Santos Laguna | - | Club León | 3:0 | ||||
| 11. Round | 30/09/2018 | Club Necaxa | - | Santos Laguna | 0:1 | ||||
| 12. Round | 06/10/2018 | Santos Laguna | - | Atlas Guadalajara | 3:1 | ||||
| 13. Round | 21/10/2018 | CF Pachuca | - | Santos Laguna | 1:1 | ||||
| 15. Round | 04/11/2018 | Gallos Blancos | - | Santos Laguna | 2:1 | ||||
| 16. Round | 12/11/2018 | Santos Laguna | - | CF América | 1:1 | ||||
| 17. Round | 25/11/2018 | Pumas UNAM | - | Santos Laguna | 1:1 |
Mexico