| 1. Round | 26/07/2020 | Cruz Azul | - | Santos Laguna | 2:0 |  |
|||
| 2. Round | 03/08/2020 | Santos Laguna | - | Deportivo Guadalajara | 2:0 | ||||
| 3. Round | 09/08/2020 | CF Monterrey | - | Santos Laguna | 2:2 | ||||
| 13. Round | 03/10/2020 | Puebla FC | - | Santos Laguna | 0:2 | ||||
| 12. Round | 12/10/2020 | Santos Laguna | - | Club Tijuana | 2:0 | ||||
| 14. Round | 19/10/2020 | Santos Laguna | - | CF Pachuca | 1:1 | ||||
| 15. Round | 26/10/2020 | Santos Laguna | - | Atlético San Luis | 2:1 | ||||
| 16. Round | 03/11/2020 | Club León | - | Santos Laguna | 2:1 | ||||
| 17. Round | 09/11/2020 | Santos Laguna | - | Mazatlán FC | 4:0 |
Mexico