| 11. Round | 13/09/2015 | San Lorenzo | - | Libertad | 0:2 |  |
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| 12. Round | 21/09/2015 | San Lorenzo | - | Guaraní | 2:2 | ||||
| 13. Round | 29/09/2015 | Club Nacional | - | San Lorenzo | 0:2 |  |
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| 14. Round | 04/10/2015 | San Lorenzo | - | Sol de América | 2:4 | ||||
| 15. Round | 18/10/2015 | Cerro Porteño | - | San Lorenzo | 1:0 | |
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| 16. Round | 25/10/2015 | San Lorenzo | - | Deportivo Capiatá | 1:5 | |
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| 17. Round | 31/10/2015 | Club Rubio Ñu | - | San Lorenzo | 3:0 | ||||
| 18. Round | 04/11/2015 | San Lorenzo | - | Deportivo Santaní | 3:2 | |
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| 20. Round | 21/11/2015 | Club Olimpia | - | San Lorenzo | 3:2 | ||||
| 21. Round | 30/11/2015 | San Lorenzo | - | Sportivo Luqueño | 2:2 | ||||
| 22. Round | 05/12/2015 | Libertad | - | San Lorenzo | 1:1 |
Paraguay