| 1. Round | 20/07/2019 | Atlético San Luis | - | Pumas UNAM | 0:2 | ||||
| 2. Round | 28/07/2019 | Atlético San Luis | - | CF Monterrey | 1:0 | ||||
| 4. Round | 11/08/2019 | Deportivo Guadalajara | - | Atlético San Luis | 3:0 | ||||
| 5. Round | 17/08/2019 | Atlético San Luis | - | UANL Tigres | 1:1 | ||||
| 6. Round | 24/08/2019 | CD Veracruz | - | Atlético San Luis | 1:2 | ||||
| 7. Round | 28/08/2019 | Atlético San Luis | - | Monarcas Morelia | 1:1 | ||||
| 8. Round | 01/09/2019 | CF Pachuca | - | Atlético San Luis | 0:2 | ||||
| 9. Round | 14/09/2019 | Puebla FC | - | Atlético San Luis | 1:3 | ||||
| 10. Round | 21/09/2019 | Atlético San Luis | - | Santos Laguna | 2:3 | ||||
| 11. Round | 27/09/2019 | Deportivo Toluca | - | Atlético San Luis | 3:1 | ||||
| 12. Round | 29/09/2019 | Atlético San Luis | - | Club Tijuana | 2:3 | ||||
| 13. Round | 07/10/2019 | FC Juárez | - | Atlético San Luis | 1:2 | ||||
| 14. Round | 20/10/2019 | Atlético San Luis | - | Gallos Blancos | 0:2 | ||||
| 15. Round | 27/10/2019 | Club León | - | Atlético San Luis | 3:2 | ||||
| 16. Round | 30/10/2019 | Atlético San Luis | - | CF América | 0:1 | ||||
| 17. Round | 02/11/2019 | Atlas Guadalajara | - | Atlético San Luis | 1:2 | ||||
| 18. Round | 09/11/2019 | Atlético San Luis | - | Club Necaxa | 0:2 |
Mexico