| 1. Round | 17/04/2021 | Caracas FC | - | Universidad Central | 2:0 | ||||
| 2. Round | 25/04/2021 | Universidad Central | - | Monagas | 0:2 |  |
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| 5. Round | 15/05/2021 | Universidad Central | - | LALA FC | 2:0 | ||||
| 7. Round | 29/05/2021 | Mineros de Guayana | - | Universidad Central | 3:1 | ||||
| 8. Round | 03/06/2021 | Universidad Central | - | Caracas FC | 2:3 | ||||
| 10. Round | 19/06/2021 | Universidad Central | - | Atlético Venezuela | 2:2 | ||||
| 12. Round | 01/07/2021 | LALA FC | - | Universidad Central | 0:2 | |
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| 13. Round | 08/07/2021 | Universidad Central | - | Metropolitanos FC | 0:0 | ||||
| 14. Round | 15/07/2021 | Universidad Central | - | Mineros de Guayana | 1:0 |  |
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| 17. Round | 06/08/2021 | Atlético Venezuela | - | Universidad Central | 1:0 |  |
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| 20. Round | 29/08/2021 | Metropolitanos FC | - | Universidad Central | 1:1 | ||||
| 23. Round | 16/09/2021 | Monagas | - | Universidad Central | 2:1 | ||||
| 27. Round | 15/10/2021 | Universidad Central | - | Metropolitanos FC | 1:1 |
Venezuela