| 1. Round | 10/01/2016 | CF Monterrey | - | Pumas UNAM | 1:0 | ||||
| 2. Round | 17/01/2016 | Puebla FC | - | CF Monterrey | 1:3 |  |
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| 3. Round | 24/01/2016 | CF Monterrey | - | Atlas Guadalajara | 1:0 | |
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| 4. Round | 31/01/2016 | CF Pachuca | - | CF Monterrey | 3:1 | ||||
| 5. Round | 07/02/2016 | CF Monterrey | - | Dorados de Sinaloa | 3:0 |  |
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| 6. Round | 13/02/2016 | Santos Laguna | - | CF Monterrey | 1:2 | |
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| 7. Round | 21/02/2016 | CF Monterrey | - | CD Veracruz | 5:1 | |
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| 8. Round | 27/02/2016 | Cruz Azul | - | CF Monterrey | 4:0 | ||||
| 9. Round | 06/03/2016 | CF Monterrey | - | UANL Tigres | 1:0 | ||||
| 10. Round | 13/03/2016 | Monarcas Morelia | - | CF Monterrey | 1:3 | ||||
| 11. Round | 20/03/2016 | CF Monterrey | - | Deportivo Guadalajara | 1:3 | ||||
| 12. Round | 03/04/2016 | Club León | - | CF Monterrey | 1:2 | ||||
| 13. Round | 10/04/2016 | CF Monterrey | - | Chiapas FC | 6:0 | |
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| 14. Round | 16/04/2016 | Club Tijuana | - | CF Monterrey | 1:2 | ||||
| 15. Round | 24/04/2016 | CF Monterrey | - | Gallos Blancos | 3:2 | |
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| 16. Round | 30/04/2016 | CF América | - | CF Monterrey | 3:3 | |
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| 17. Round | 08/05/2016 | CF Monterrey | - | Deportivo Toluca | 1:2 |
Uruguay
Argentina