| 22. Round | 21/08/2021 | Barracas Central | - | Güemes de SdE | 1:0 | ||||
| 23. Round | 29/08/2021 | Deportivo Morón | - | Barracas Central | 2:0 | ||||
| 24. Round | 03/09/2021 | Barracas Central | - | Ferro Carril Oeste | 0:0 | ||||
| 25. Round | 10/09/2021 | Tristan Suárez | - | Barracas Central | 2:2 |  |
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| 26. Round | 18/09/2021 | Barracas Central | - | Gimnasia de Jujuy | 1:1 | ||||
| 27. Round | 26/09/2021 | Instituto de Córdoba | - | Barracas Central | 1:0 | ||||
| 28. Round | 02/10/2021 | Barracas Central | - | All Boys | 2:1 | ||||
| 30. Round | 16/10/2021 | Atlético Rafaela | - | Barracas Central | 0:2 | ||||
| 31. Round | 23/10/2021 | Barracas Central | - | Guillermo Brown | 0:0 | ||||
| 32. Round | 31/10/2021 | Brown de Adrogué | - | Barracas Central | 1:2 | ||||
| 33. Round | 07/11/2021 | Barracas Central | - | San Martín de San Juan | 3:0 | ||||
| 34. Round | 15/11/2021 | Villa Dálmine | - | Barracas Central | 1:3 |
Argentina