| 1. Round | 06/05/2021 | Deportivo Cuenca [Women] | - | Técnico Universitario [Women] | 1:0 | ||||
| 2. Round | 13/05/2021 | Deportivo Cuenca [Women] | - | Barcelona [Women] | 4:1 | ||||
| 3. Round | 17/05/2021 | Guayaquil City [Women] | - | Deportivo Cuenca [Women] | 1:8 |  |
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| 4. Round | 22/05/2021 | Deportivo Cuenca [Women] | - | Macará [Women] | 6:0 | ||||
| 6. Round | 04/06/2021 | Deportivo Cuenca [Women] | - | Emelec [Women] | 6:0 | ||||
| 8. Round | 19/06/2021 | Técnico Universitario [Women] | - | Deportivo Cuenca [Women] | 0:5 | |
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| 9. Round | 26/06/2021 | Barcelona [Women] | - | Deportivo Cuenca [Women] | 0:0 | ||||
| 10. Round | 02/07/2021 | Deportivo Cuenca [Women] | - | Guayaquil City [Women] | 7:0 | ||||
| 11. Round | 11/07/2021 | Macará [Women] | - | Deportivo Cuenca [Women] | 0:1 |
Ecuador