| 1. Round | 17/10/2020 | Sol de América | - | Guaraní | 1:0 |  |
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| 2. Round | 26/10/2020 | Guaraní | - | Cerro Porteño | 1:1 |  |
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| 3. Round | 01/11/2020 | River Plate | - | Guaraní | 1:0 | ||||
| 4. Round | 06/11/2020 | Guaraní | - | General Díaz | 2:0 | |
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| 5. Round | 12/11/2020 | Club Nacional | - | Guaraní | 0:0 | ||||
| 6. Round | 16/11/2020 | Guaraní | - | San Lorenzo | 2:1 | ||||
| 7. Round | 21/11/2020 | 12 de Octubre de Itauguá | - | Guaraní | 1:0 | |
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| 8. Round | 29/11/2020 | Guaraní | - | Sportivo Luqueño | 2:1 | |
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| 9. Round | 06/12/2020 | Guaraní | - | Club Olimpia | 2:0 | ||||
| 10. Round | 11/12/2020 | Libertad | - | Guaraní | 1:1 | ||||
| 11. Round | 19/12/2020 | Guaraní | - | Guaireña FC | 1:0 |
Paraguay