| 1. Round | 30/07/2022 | FC Zimbru | - | FC Sheriff | 1:1 | ||||
| 2. Round | 06/08/2022 | FC Sfîntul Gheorghe | - | FC Sheriff | 1:3 | ||||
| 3. Round | 14/08/2022 | FC Sheriff | - | Dinamo-Auto | 2:0 | ||||
| 5. Round | 29/08/2022 | FC Sheriff | - | CS Petrocub | 1:1 | ||||
| 6. Round | 03/09/2022 | Dacia Buiucani | - | FC Sheriff | 0:2 | ||||
| 7. Round | 11/09/2022 | FC Sheriff | - | FC Milsami | 2:0 | ||||
| 9. Round | 02/10/2022 | FC Sheriff | - | FC Sfîntul Gheorghe | 3:0 | ||||
| 10. Round | 09/10/2022 | Dinamo-Auto | - | FC Sheriff | 0:1 | ||||
| 11. Round | 16/10/2022 | FC Sheriff | - | FC Bălţi | 2:1 | ||||
| 13. Round | 30/10/2022 | FC Sheriff | - | Dacia Buiucani | 2:1 |  |
Burkina Faso