| 5. Round | 23/07/2022 | FC Juárez [U16] | - | Deportivo Toluca [U16] | 0:4 |  |
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| 6. Round | 30/07/2022 | Deportivo Toluca [U16] | - | CF América [U16] | 2:5 | ||||
| 8. Round | 13/08/2022 | Deportivo Toluca [U16] | - | Cruz Azul [U16] | 3:3 | ||||
| 9. Round | 07/09/2022 | Gallos Blancos [U16] | - | Deportivo Toluca [U16] | 1:3 | ||||
| 12. Round | 10/09/2022 | Deportivo Toluca [U16] | - | Pumas UNAM [U16] | 2:1 | ||||
| 13. Round | 17/09/2022 | CF Pachuca [U16] | - | Deportivo Toluca [U16] | 1:2 | ||||
| 16. Round | 08/10/2022 | Deportivo Toluca [U16] | - | Puebla FC [U16] | 3:1 | ||||
| 17. Round | 15/10/2022 | Cruz Azul [U16] | - | Deportivo Toluca [U16] | 3:2 | ||||
| 18. Round | 22/10/2022 | Deportivo Toluca [U16] | - | Gallos Blancos [U16] | 1:1 |
Mexico