| 1. Round | 04/01/2025 | Atlas Guadalajara [Women] | - | Santos Laguna [Women] | 1:3 | ||||
| 2. Round | 10/01/2025 | Santos Laguna [Women] | - | Deportivo Guadalajara [Women] | 0:1 | ||||
| 4. Round | 22/01/2025 | Santos Laguna [Women] | - | Club Necaxa [Women] | 2:3 | ||||
| 9. Round | 14/02/2025 | Santos Laguna [Women] | - | CF Pachuca [Women] | 1:3 | ||||
| 10. Round | 05/03/2025 | Gallos Blancos [Women] | - | Santos Laguna [Women] | 3:0 | ||||
| 13. Round | 19/03/2025 | Santos Laguna [Women] | - | CF Monterrey [Women] | 1:3 | ||||
| 14. Round | 23/03/2025 | Puebla FC [Women] | - | Santos Laguna [Women] | 2:1 |  |
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| 15. Round | 29/03/2025 | Santos Laguna [Women] | - | CF América [Women] | 0:3 | ||||
| 16. Round | 15/04/2025 | Club León [Women] | - | Santos Laguna [Women] | 3:1 | ||||
| 17. Round | 18/04/2025 | Mazatlán FC [Women] | - | Santos Laguna [Women] | 1:2 | |
Mexico