| 2. Round | 22/01/2022 | Alacranes de Durango | - | Saltillo FC | 3:1 | ||||
| 3. Round | 29/01/2022 | Saltillo FC | - | Cimarrones de Sonora II | 2:1 | ||||
| 9. Round | 12/03/2022 | Tecos Fútbol Club | - | Saltillo FC | 1:2 |  |
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| 10. Round | 19/03/2022 | Saltillo FC | - | Colima FC | 2:1 | ||||
| 11. Round | 26/03/2022 | Leones Negros II | - | Saltillo FC | 2:1 | ||||
| 12. Round | 02/04/2022 | Saltillo FC | - | Coras de Nayarit | 2:1 | ||||
| 13. Round | 09/04/2022 | Mineros de Fresnillo FC | - | Saltillo FC | 0:5 |
Mexico