| 1. Round | 08/01/2012 | Santos Laguna | - | CF Pachuca | 0:0 |  |
|||
| 6. Round | 11/02/2012 | Monarcas Morelia | - | Santos Laguna | 3:1 |  |
|||
| 7. Round | 19/02/2012 | Santos Laguna | - | CF Monterrey | 1:1 | ||||
| 8. Round | 26/02/2012 | Deportivo Guadalajara | - | Santos Laguna | 2:1 | ||||
| 9. Round | 04/03/2012 | Santos Laguna | - | Club San Luis | 5:2 | |
|||
| 11. Round | 18/03/2012 | Cruz Azul | - | Santos Laguna | 0:1 | |
|||
| 15. Round | 14/04/2012 | CF América | - | Santos Laguna | 3:1 | ||||
| 16. Round | 22/04/2012 | Santos Laguna | - | UANL Tigres | 3:0 |
Mexico