| 1. Round | 17/07/2022 | Club Olimpia | - | Guaraní | 2:0 | ||||
| 4. Round | 31/07/2022 | Guaraní | - | 12 de Octubre de Itauguá | 0:1 | ||||
| 10. Round | 11/09/2022 | Tacuary | - | Guaraní | 2:0 | ||||
| 13. Round | 24/09/2022 | General Caballero DJLM | - | Guaraní | 3:0 | ||||
| 17. Round | 17/10/2022 | Club Nacional | - | Guaraní | 2:0 |  |
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| 18. Round | 23/10/2022 | Guaraní | - | Cerro Porteño | 1:2 | ||||
| 20. Round | 30/10/2022 | Guaireña FC | - | Guaraní | 1:0 |
Paraguay