| 1. Round | 26/01/2025 | Club Olimpia | - | Guaraní | 0:1 |  |
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| 2. Round | 30/01/2025 | Sportivo Ameliano | - | Club Olimpia | 2:2 | |
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| 3. Round | 03/02/2025 | Club Olimpia | - | Atlético Tembetary | 3:0 | ||||
| 5. Round | 16/02/2025 | Club Olimpia | - | Sportivo Trinidense | 4:2 | ||||
| 6. Round | 23/02/2025 | Club Olimpia | - | Cerro Porteño | 2:1 | ||||
| 7. Round | 01/03/2025 | General Caballero DJLM | - | Club Olimpia | 1:1 | ||||
| 8. Round | 09/03/2025 | Club Olimpia | - | 2 de Mayo | 2:1 | ||||
| 9. Round | 15/03/2025 | Libertad | - | Club Olimpia | 2:1 | |
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| 10. Round | 22/03/2025 | Club Olimpia | - | Club Nacional | 0:1 | |
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| 11. Round | 29/03/2025 | Deportivo Recoleta | - | Club Olimpia | 1:1 | ||||
| 13. Round | 13/04/2025 | Club Olimpia | - | Sportivo Ameliano | 0:0 | ||||
| 17. Round | 03/05/2025 | Cerro Porteño | - | Club Olimpia | 1:2 |
Paraguay