| 1. Round | 09/01/2021 | CF América [U20] | - | Atlético San Luis [U20] | 4:1 | ||||
| 2. Round | 15/01/2021 | Club Necaxa [U20] | - | Atlético San Luis [U20] | 2:1 | ||||
| 3. Round | 21/01/2021 | Atlético San Luis [U20] | - | Deportivo Guadalajara [U20] | 3:2 |  |
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| 5. Round | 04/02/2021 | Atlético San Luis [U20] | - | Club Tijuana [U20] | 1:2 | ||||
| 6. Round | 12/02/2021 | Mazatlán FC [U20] | - | Atlético San Luis [U20] | 1:0 | ||||
| 10. Round | 05/03/2021 | Atlético San Luis [U20] | - | Deportivo Toluca [U20] | 1:2 | ||||
| 11. Round | 14/03/2021 | Gallos Blancos [U20] | - | Atlético San Luis [U20] | 0:1 | ||||
| 4. Round | 26/03/2021 | Club León [U20] | - | Atlético San Luis [U20] | 4:2 | ||||
| 14. Round | 09/04/2021 | FC Juárez [U20] | - | Atlético San Luis [U20] | 2:2 | |
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| 15. Round | 17/04/2021 | Atlético San Luis [U20] | - | Puebla FC [U20] | 5:3 | ||||
| 16. Round | 24/04/2021 | Cruz Azul [U20] | - | Atlético San Luis [U20] | 0:1 |
Mexico