| 3. Round | 06/08/2021 | Mazatlán FC [U20] | - | CF Monterrey [U20] | 1:4 | ||||
| 4. Round | 14/08/2021 | CF Monterrey [U20] | - | CF Pachuca [U20] | 1:1 | ||||
| 5. Round | 18/08/2021 | Cruz Azul [U20] | - | CF Monterrey [U20] | 2:1 | ||||
| 8. Round | 11/09/2021 | Atlas Guadalajara [U20] | - | CF Monterrey [U20] | 3:1 | ||||
| 9. Round | 19/09/2021 | CF Monterrey [U20] | - | UANL Tigres [U20] | 0:1 | ||||
| 10. Round | 26/09/2021 | Santos Laguna [U20] | - | CF Monterrey [U20] | 4:1 | ||||
| 12. Round | 01/10/2021 | FC Juárez [U20] | - | CF Monterrey [U20] | 1:0 | ||||
| 13. Round | 16/10/2021 | CF Monterrey [U20] | - | Club León [U20] | 1:1 | ||||
| 14. Round | 19/10/2021 | Gallos Blancos [U20] | - | CF Monterrey [U20] | 1:1 |
Mexico