| 2. Round | 18/07/2022 | Puebla FC [Women] | - | Pumas UNAM [Women] | 1:2 | ||||
| 3. Round | 23/07/2022 | Pumas UNAM [Women] | - | Deportivo Toluca [Women] | 1:2 |  |
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| 4. Round | 29/07/2022 | FC Juárez [Women] | - | Pumas UNAM [Women] | 1:4 | ||||
| 5. Round | 01/08/2022 | Club Necaxa [Women] | - | Pumas UNAM [Women] | 2:2 | ||||
| 6. Round | 06/08/2022 | Pumas UNAM [Women] | - | Atlético San Luis [Women] | 3:0 | ||||
| 7. Round | 16/08/2022 | Santos Laguna [Women] | - | Pumas UNAM [Women] | 1:2 | ||||
| 9. Round | 24/08/2022 | Pumas UNAM [Women] | - | Gallos Blancos [Women] | 1:1 | ||||
| 13. Round | 23/09/2022 | Pumas UNAM [Women] | - | Deportivo Guadalajara [Women] | 1:2 | ||||
| 14. Round | 27/09/2022 | CF Monterrey [Women] | - | Pumas UNAM [Women] | 6:0 | ||||
| 16. Round | 17/10/2022 | CF América [Women] | - | Pumas UNAM [Women] | 6:1 | ||||
| 17. Round | 21/10/2022 | Pumas UNAM [Women] | - | Atlas Guadalajara [Women] | 3:2 |
USA