| 2. Round | 10/04/2022 | El Paso Locomotive | - | Monterey Bay FC | 5:0 |  |
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| 2. Round | 17/04/2022 | San Antonio FC | - | El Paso Locomotive | 1:0 | ||||
| 2. Round | 24/04/2022 | El Paso Locomotive | - | Oakland Roots | 1:1 | ||||
| 3. Round | 30/04/2022 | Loudoun United | - | El Paso Locomotive | 1:3 | |
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| 3. Round | 05/05/2022 | El Paso Locomotive | - | FC Tulsa | 3:1 | ||||
| 3. Round | 15/05/2022 | Pittsburgh Riverhounds | - | El Paso Locomotive | 1:0 | ||||
| 3. Round | 19/05/2022 | El Paso Locomotive | - | Sacramento Republic | 1:0 |
USA