| 1. Round | 06/08/2022 | Borussia Dortmund | - | Bayer Leverkusen | 1:0 | ||||
| 2. Round | 13/08/2022 | Bayer Leverkusen | - | FC Augsburg | 1:2 |  |
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| 3. Round | 20/08/2022 | Bayer Leverkusen | - | 1899 Hoffenheim | 0:3 | ||||
| 4. Round | 27/08/2022 | 1. FSV Mainz 05 | - | Bayer Leverkusen | 0:3 | ||||
| 5. Round | 03/09/2022 | Bayer Leverkusen | - | SC Freiburg | 2:3 | ||||
| 6. Round | 10/09/2022 | Hertha BSC | - | Bayer Leverkusen | 2:2 |  |
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| 7. Round | 17/09/2022 | Bayer Leverkusen | - | Werder Bremen | 1:1 | ||||
| 8. Round | 30/09/2022 | Bayern München | - | Bayer Leverkusen | 4:0 | ||||
| 9. Round | 08/10/2022 | Bayer Leverkusen | - | FC Schalke 04 | 4:0 | ||||
| 10. Round | 15/10/2022 | Eintracht Frankfurt | - | Bayer Leverkusen | 5:1 |
Chile
