| 1. Round | 06/08/2011 | Hannover 96 | - | 1899 Hoffenheim | 2:1 |  |
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| 2. Round | 13/08/2011 | 1899 Hoffenheim | - | Borussia Dortmund | 1:0 | |
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| 3. Round | 20/08/2011 | FC Augsburg | - | 1899 Hoffenheim | 0:2 | ||||
| 4. Round | 27/08/2011 | 1899 Hoffenheim | - | Werder Bremen | 1:2 | ||||
| 5. Round | 10/09/2011 | 1. FSV Mainz 05 | - | 1899 Hoffenheim | 0:4 | ||||
| 6. Round | 17/09/2011 | 1899 Hoffenheim | - | VfL Wolfsburg | 3:1 | ||||
| 7. Round | 25/09/2011 | 1. FC Köln | - | 1899 Hoffenheim | 2:0 | ||||
| 8. Round | 01/10/2011 | 1899 Hoffenheim | - | Bayern München | 0:0 | ||||
| 9. Round | 15/10/2011 | VfB Stuttgart | - | 1899 Hoffenheim | 2:0 | |
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| 10. Round | 22/10/2011 | 1899 Hoffenheim | - | Bor. Mönchengladbach | 1:0 | ||||
| 11. Round | 29/10/2011 | FC Schalke 04 | - | 1899 Hoffenheim | 3:1 | ||||
| 12. Round | 05/11/2011 | 1899 Hoffenheim | - | 1. FC Kaiserslautern | 1:1 | ||||
| 14. Round | 26/11/2011 | 1899 Hoffenheim | - | SC Freiburg | 1:1 |
Nigeria
