| 1. Round | 12/01/2025 | Deportivo Guadalajara | - | Santos Laguna | 1:0 |  |
|||
| 3. Round | 26/01/2025 | Santos Laguna | - | CF América | 1:4 |  |
|||
| 4. Round | 30/01/2025 | FC Juárez | - | Santos Laguna | 1:0 | ||||
| 5. Round | 02/02/2025 | Santos Laguna | - | Puebla FC | 0:2 | ||||
| 6. Round | 08/02/2025 | Club Necaxa | - | Santos Laguna | 3:2 |  |
|||
| 13. Round | 31/03/2025 | Santos Laguna | - | Atlético San Luis | 2:3 | ||||
| 14. Round | 07/04/2025 | Deportivo Toluca | - | Santos Laguna | 2:1 | ||||
| 16. Round | 17/04/2025 | Pumas UNAM | - | Santos Laguna | 2:0 | ||||
| 17. Round | 21/04/2025 | Santos Laguna | - | Club Tijuana | 0:4 | |
Honduras
Spain