1. Round | 24/07/2021 | MFK Ružomberok | - | FK Senica | 0:0 | ||||
2. Round | 01/08/2021 | FK Senica | - | Spartak Trnava | 2:1 | ||||
3. Round | 06/08/2021 | Zlaté Moravce | - | FK Senica | 1:1 | ||||
4. Round | 14/08/2021 | FK Senica | - | FC DAC 1904 | 1:1 | ||||
5. Round | 22/08/2021 | MŠK Žilina | - | FK Senica | 3:0 | ||||
6. Round | 28/08/2021 | Tatran Liptovský Mikuláš | - | FK Senica | 1:2 |