| 2. Round | 14/08/2021 | Progrès Niedercorn | - | F91 Dudelange | 2:2 | ||||
| 3. Round | 22/08/2021 | Jeunesse Esch | - | F91 Dudelange | 0:3 | ||||
| 10. Round | 24/10/2021 | F91 Dudelange | - | Victoria Rosport | 4:1 |  |
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| 11. Round | 06/11/2021 | CS FOLA Esch | - | F91 Dudelange | 0:3 | ||||
| 15. Round | 11/12/2021 | RM Hamm Benfica | - | F91 Dudelange | 0:4 | |
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| 18. Round | 20/02/2022 | US Hostert | - | F91 Dudelange | 1:3 | |
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| 19. Round | 26/02/2022 | F91 Dudelange | - | RFCU Luxemburg | 1:1 | |
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| 21. Round | 12/03/2022 | F91 Dudelange | - | US Mondorf | 2:1 | ||||
| 22. Round | 20/03/2022 | Etzella Ettelbruck | - | F91 Dudelange | 0:4 | ||||
| 23. Round | 03/04/2022 | F91 Dudelange | - | FC Differdange 03 | 1:0 | |
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| 26. Round | 24/04/2022 | UNA Strassen | - | F91 Dudelange | 3:1 | ||||
| 27. Round | 01/05/2022 | F91 Dudelange | - | Swift Hesperange | 1:0 | ||||
| 29. Round | 15/05/2022 | F91 Dudelange | - | RM Hamm Benfica | 7:0 | ||||
| 30. Round | 22/05/2022 | FC Wiltz 71 | - | F91 Dudelange | 0:3 |
Luxembourg