| 6. Round | 11/09/2010 | KV Kortrijk | - | KV Mechelen | 1:0 | ||||
| 8. Round | 22/09/2010 | KV Mechelen | - | Cercle Brugge | 2:2 |  |
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| 9. Round | 26/09/2010 | RSC Anderlecht | - | KV Mechelen | 5:0 | ||||
| 11. Round | 16/10/2010 | KVC Westerlo | - | KV Mechelen | 1:1 | ||||
| 12. Round | 23/10/2010 | KV Mechelen | - | Germinal Beerschot | 5:1 |  |
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| 13. Round | 30/10/2010 | KAA Gent | - | KV Mechelen | 3:1 |  |
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| 14. Round | 06/11/2010 | KV Mechelen | - | Sporting Charleroi | 2:0 | ||||
| 16. Round | 20/11/2010 | Sporting Lokeren | - | KV Mechelen | 3:1 | |
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| 17. Round | 28/11/2010 | KV Mechelen | - | SV Zulte Waregem | 0:0 | ||||
| 19. Round | 10/12/2010 | KV Mechelen | - | Club Brugge KV | 0:1 | |
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| 20. Round | 23/02/2011 | Sint-Truidense VV | - | KV Mechelen | 0:1 | |
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| 28. Round | 05/03/2011 | KV Mechelen | - | KAA Gent | 1:1 | |
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| 29. Round | 12/03/2011 | Germinal Beerschot | - | KV Mechelen | 1:1 | ||||
| 30. Round | 20/03/2011 | KV Mechelen | - | KAS Eupen | 2:0 |
Congo DR
