| 1. Round | 25/08/2012 | River Plate | - | Juventud de Las Piedras | 1:0 | ||||
| 2. Round | 02/09/2012 | Peñarol | - | River Plate | 1:1 |  |
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| 3. Round | 16/09/2012 | River Plate | - | Racing | 2:2 | ||||
| 4. Round | 23/09/2012 | El Tanque Sisley | - | River Plate | 1:0 | ||||
| 5. Round | 30/09/2012 | River Plate | - | Liverpool | 2:0 | ||||
| 6. Round | 07/10/2012 | River Plate | - | Montevideo Wanderers | 1:3 | ||||
| 7. Round | 13/10/2012 | River Plate | - | Progreso | 0:0 | |
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| 8. Round | 20/10/2012 | River Plate | - | Bella Vista | 0:2 | ||||
| 9. Round | 28/10/2012 | Cerro Largo | - | River Plate | 2:2 | ||||
| 10. Round | 03/11/2012 | Nacional | - | River Plate | 0:2 | |
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| 11. Round | 10/11/2012 | River Plate | - | CA Cerro | 0:1 | ||||
| 12. Round | 17/11/2012 | Danubio | - | River Plate | 0:2 | ||||
| 13. Round | 24/11/2012 | River Plate | - | Defensor Sporting | 1:1 | ||||
| 14. Round | 02/12/2012 | Central Español | - | River Plate | 2:5 | ||||
| 15. Round | 08/12/2012 | Fénix | - | River Plate | 2:2 | |
Uruguay