| 1. Round | 15/08/2015 | River Plate | - | Fénix | 1:2 | ||||
| 2. Round | 23/08/2015 | Nacional | - | River Plate | 2:1 | ||||
| 3. Round | 29/08/2015 | River Plate | - | Sud América | 2:0 | ||||
| 4. Round | 05/09/2015 | Montevideo Wanderers | - | River Plate | 5:1 |  |
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| 7. Round | 27/09/2015 | River Plate | - | Peñarol | 4:0 | ||||
| 8. Round | 04/10/2015 | Juventud de Las Piedras | - | River Plate | 2:3 | ||||
| 9. Round | 18/10/2015 | River Plate | - | Danubio | 2:1 | ||||
| 10. Round | 25/10/2015 | CA Cerro | - | River Plate | 1:1 |  |
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| 13. Round | 21/11/2015 | River Plate | - | Liverpool | 2:2 | |
Uruguay