| 7. Round | 02/04/2022 | Cobreloa | - | Puerto Montt | 2:1 | ||||
| 8. Round | 09/04/2022 | Deportes Melipilla | - | Cobreloa | 0:0 | ||||
| 9. Round | 17/04/2022 | Deportes Iquique | - | Cobreloa | 2:0 | ||||
| 10. Round | 21/04/2022 | Cobreloa | - | Barnechea | 3:2 | ||||
| 11. Round | 24/04/2022 | Cobreloa | - | Recoleta | 3:0 | ||||
| 12. Round | 29/04/2022 | Unión San Felipe | - | Cobreloa | 1:1 | ||||
| 16. Round | 22/05/2022 | Cobreloa | - | Fernández Vial | 1:0 | ||||
| 17. Round | 28/05/2022 | Santiago Morning | - | Cobreloa | 0:1 | ||||
| 5. Round | 02/06/2022 | Cobreloa | - | Santa Cruz | 1:0 |  |
|||
| 21. Round | 24/07/2022 | Cobreloa | - | Rangers | 1:0 | ||||
| 24. Round | 12/08/2022 | Puerto Montt | - | Cobreloa | 1:1 | ||||
| 26. Round | 31/08/2022 | Cobreloa | - | Deportes Iquique | 2:1 | ||||
| 29. Round | 26/09/2022 | Cobreloa | - | Unión San Felipe | 1:0 | ||||
| 33. Round | 23/10/2022 | Fernández Vial | - | Cobreloa | 2:3 | ||||
| 34. Round | 01/11/2022 | Cobreloa | - | Santiago Morning | 2:2 |
Chile