| 1. Round | 25/07/2010 | Club San Luis | - | CF Monterrey | 1:1 | ||||
| 2. Round | 01/08/2010 | Puebla FC | - | Club San Luis | 2:1 | ||||
| 3. Round | 08/08/2010 | Club San Luis | - | Deportivo Guadalajara | 0:1 | ||||
| 4. Round | 15/08/2010 | Club San Luis | - | Monarcas Morelia | 1:0 | ||||
| 5. Round | 21/08/2010 | Estudiantes Tecos | - | Club San Luis | 3:2 | ||||
| 10. Round | 03/10/2010 | Club San Luis | - | UANL Tigres | 1:0 | ||||
| 11. Round | 10/10/2010 | Atlas Guadalajara | - | Club San Luis | 2:1 |  |
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| 12. Round | 16/10/2010 | Club San Luis | - | Gallos Blancos (old) | 3:2 |
Mexico