| 1. Round | 08/01/2012 | Santos Laguna | - | CF Pachuca | 0:0 | ||||
| 2. Round | 15/01/2012 | Atlante | - | Santos Laguna | 1:2 |  |
|||
| 3. Round | 22/01/2012 | Santos Laguna | - | Jaguares Chiapas | 1:0 | ||||
| 4. Round | 29/01/2012 | Club Tijuana | - | Santos Laguna | 1:3 | |
|||
| 5. Round | 05/02/2012 | Santos Laguna | - | Pumas UNAM | 2:1 | |
|||
| 6. Round | 11/02/2012 | Monarcas Morelia | - | Santos Laguna | 3:1 | ||||
| 7. Round | 19/02/2012 | Santos Laguna | - | CF Monterrey | 1:1 | ||||
| 8. Round | 26/02/2012 | Deportivo Guadalajara | - | Santos Laguna | 2:1 | ||||
| 9. Round | 04/03/2012 | Santos Laguna | - | Club San Luis | 5:2 | ||||
| 10. Round | 11/03/2012 | Santos Laguna | - | Puebla FC | 3:1 |  |
|||
| 12. Round | 25/03/2012 | Santos Laguna | - | Gallos Blancos (old) | 2:0 | ||||
| 13. Round | 01/04/2012 | Deportivo Toluca | - | Santos Laguna | 1:3 | |
|||
| 14. Round | 08/04/2012 | Santos Laguna | - | Estudiantes Tecos | 1:1 | ||||
| 16. Round | 22/04/2012 | Santos Laguna | - | UANL Tigres | 3:0 | ||||
| 17. Round | 29/04/2012 | Atlas Guadalajara | - | Santos Laguna | 1:3 |
Ecuador