| 1. Round | 22/07/2012 | Santos Laguna | - | Club San Luis | 2:1 |  |
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| 2. Round | 29/07/2012 | Deportivo Guadalajara | - | Santos Laguna | 0:1 | ||||
| 3. Round | 04/08/2012 | Santos Laguna | - | Puebla FC | 2:2 | ||||
| 4. Round | 11/08/2012 | Club León | - | Santos Laguna | 3:0 | ||||
| 11. Round | 04/10/2012 | Santos Laguna | - | Atlas Guadalajara | 2:1 | ||||
| 12. Round | 07/10/2012 | Gallos Blancos (old) | - | Santos Laguna | 1:1 | ||||
| 13. Round | 14/10/2012 | Santos Laguna | - | Club Tijuana | 2:2 | ||||
| 15. Round | 28/10/2012 | CF Monterrey | - | Santos Laguna | 3:2 | ||||
| 16. Round | 03/11/2012 | Santos Laguna | - | Cruz Azul | 2:1 | ||||
| 17. Round | 10/11/2012 | Monarcas Morelia | - | Santos Laguna | 2:0 |
Ecuador