| 2. Round | 21/08/2021 | Royal Excel Mouscron | - | Lommel SK | 0:1 | ||||
| 3. Round | 29/08/2021 | Royal Excel Mouscron | - | Waasland-Beveren | 0:4 | ||||
| 4. Round | 10/09/2021 | SK Deinze | - | Royal Excel Mouscron | 3:1 | ||||
| 5. Round | 18/09/2021 | Royal Excel Mouscron | - | Excelsior Virton | 1:1 | ||||
| 6. Round | 26/09/2021 | Royal Excel Mouscron | - | KVC Westerlo | 1:2 |  |
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| 7. Round | 02/10/2021 | Lierse Kempenzonen | - | Royal Excel Mouscron | 2:2 | ||||
| 14. Round | 05/12/2021 | KVC Westerlo | - | Royal Excel Mouscron | 4:3 | ||||
| 15. Round | 11/12/2021 | Royal Excel Mouscron | - | Lommel SK | 2:1 | |
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| 16. Round | 18/12/2021 | SK Deinze | - | Royal Excel Mouscron | 2:2 |  |
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| 17. Round | 23/01/2022 | Royal Excel Mouscron | - | Lierse Kempenzonen | 0:0 | ||||
| 18. Round | 30/01/2022 | RWD Molenbeek | - | Royal Excel Mouscron | 2:0 | ||||
| 19. Round | 05/02/2022 | Royal Excel Mouscron | - | Waasland-Beveren | 3:0 | ||||
| 21. Round | 20/02/2022 | Royal Excel Mouscron | - | Excelsior Virton | 2:1 | ||||
| 24. Round | 13/03/2022 | Lierse Kempenzonen | - | Royal Excel Mouscron | 0:1 | ||||
| 26. Round | 03/04/2022 | Excelsior Virton | - | Royal Excel Mouscron | 2:0 |
Senegal