| 3. Round | 20/08/2005 | Club Brugge KV | - | KSV Roeselare | 1:0 | ||||
| 6. Round | 18/09/2005 | KSV Roeselare | - | KVC Westerlo | 0:2 | ||||
| 7. Round | 21/09/2005 | RSC Anderlecht | - | KSV Roeselare | 5:1 | ||||
| 8. Round | 25/09/2005 | KSV Roeselare | - | KAA Gent | 1:1 | ||||
| 15. Round | 14/12/2005 | FC Brussels | - | KSV Roeselare | 1:0 | ||||
| 18. Round | 17/12/2005 | KSV Roeselare | - | Sint-Truidense VV | 1:1 | ||||
| 19. Round | 21/01/2006 | KSK Beveren | - | KSV Roeselare | 1:1 | ||||
| 23. Round | 18/02/2006 | KVC Westerlo | - | KSV Roeselare | 3:2 | ||||
| 22. Round | 21/02/2006 | KSV Roeselare | - | Sporting Charleroi | 2:0 | ||||
| 24. Round | 24/02/2006 | KSV Roeselare | - | RSC Anderlecht | 0:2 | ||||
| 28. Round | 26/03/2006 | KSV Roeselare | - | Cercle Brugge | 1:0 | ||||
| 32. Round | 22/04/2006 | KSV Roeselare | - | FC Brussels | 0:1 | ||||
| 34. Round | 05/05/2006 | Lierse SK (old) | - | KSV Roeselare | 1:0 |
Belgium