| 10. Round | 23/10/2021 | FC Wiltz 71 | - | CS FOLA Esch | 1:1 | ||||
| 11. Round | 07/11/2021 | UNA Strassen | - | FC Wiltz 71 | 3:2 |  |
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| 15. Round | 11/12/2021 | FC Wiltz 71 | - | Progrès Niedercorn | 1:3 | ||||
| 17. Round | 13/02/2022 | FC Wiltz 71 | - | US Hostert | 0:0 | ||||
| 18. Round | 20/02/2022 | RFCU Luxemburg | - | FC Wiltz 71 | 1:3 | ||||
| 19. Round | 27/02/2022 | FC Wiltz 71 | - | Union Titus Pétange | 3:2 | ||||
| 20. Round | 06/03/2022 | US Mondorf | - | FC Wiltz 71 | 2:0 | ||||
| 21. Round | 12/03/2022 | FC Wiltz 71 | - | Etzella Ettelbruck | 1:2 | ||||
| 22. Round | 20/03/2022 | FC Differdange 03 | - | FC Wiltz 71 | 3:1 | ||||
| 23. Round | 03/04/2022 | FC Wiltz 71 | - | Victoria Rosport | 1:1 | |
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| 24. Round | 10/04/2022 | CS FOLA Esch | - | FC Wiltz 71 | 2:1 | ||||
| 26. Round | 24/04/2022 | Swift Hesperange | - | FC Wiltz 71 | 3:2 | ||||
| 27. Round | 01/05/2022 | FC Wiltz 71 | - | FC Rodange 91 | 2:0 | |
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| 28. Round | 07/05/2022 | RM Hamm Benfica | - | FC Wiltz 71 | 0:6 | ||||
| 29. Round | 15/05/2022 | Progrès Niedercorn | - | FC Wiltz 71 | 2:1 | ||||
| 30. Round | 22/05/2022 | FC Wiltz 71 | - | F91 Dudelange | 0:3 |
Luxembourg