| 2. Round | 18/01/2021 | Gallos Blancos | - | Atlas Guadalajara | 1:0 | ||||
| 3. Round | 24/01/2021 | Atlas Guadalajara | - | UANL Tigres | 0:2 | ||||
| 9. Round | 02/03/2021 | Atlas Guadalajara | - | Atlético San Luis | 3:1 | ||||
| 12. Round | 21/03/2021 | Cruz Azul | - | Atlas Guadalajara | 3:2 | ||||
| 15. Round | 17/04/2021 | Mazatlán FC | - | Atlas Guadalajara | 0:0 | ||||
| 16. Round | 25/04/2021 | Atlas Guadalajara | - | Deportivo Guadalajara | 0:1 | ||||
| 17. Round | 01/05/2021 | Club Necaxa | - | Atlas Guadalajara | 1:5 |
Mexico