| 1. Round | 25/07/2021 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
| 2. Round | 01/08/2021 | Atlas Guadalajara | - | FC Juárez | 2:0 |  |
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| 4. Round | 15/08/2021 | Atlas Guadalajara | - | CF América | 0:1 | ||||
| 7. Round | 29/08/2021 | UANL Tigres | - | Atlas Guadalajara | 1:1 | ||||
| 10. Round | 25/09/2021 | Atlas Guadalajara | - | Club León | 2:0 | ||||
| 11. Round | 29/09/2021 | Atlas Guadalajara | - | Puebla FC | 0:1 | ||||
| 12. Round | 03/10/2021 | Deportivo Guadalajara | - | Atlas Guadalajara | 0:1 | ||||
| 13. Round | 16/10/2021 | Mazatlán FC | - | Atlas Guadalajara | 1:0 | ||||
| 14. Round | 20/10/2021 | Atlas Guadalajara | - | Cruz Azul | 0:0 | ||||
| 16. Round | 29/10/2021 | Atlas Guadalajara | - | Club Tijuana | 0:2 | ||||
| 17. Round | 05/11/2021 | Atlas Guadalajara | - | Gallos Blancos | 2:0 | |
Mexico