| 1. Round | 11/09/2021 | Panathinaikos | - | Apollon Smyrnis | 4:0 | ||||
| 2. Round | 19/09/2021 | Apollon Smyrnis | - | Volos NFC | 1:3 | ||||
| 6. Round | 16/10/2021 | Apollon Smyrnis | - | Asteras Tripolis | 0:1 |  |
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| 7. Round | 23/10/2021 | Apollon Smyrnis | - | PAS Giannina | 1:0 | |
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| 8. Round | 30/10/2021 | PAOK Saloniki | - | Apollon Smyrnis | 4:1 | ||||
| 11. Round | 27/11/2021 | Apollon Smyrnis | - | Lamia | 0:0 | |
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| 12. Round | 04/12/2021 | Atromitos | - | Apollon Smyrnis | 4:1 |  |
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| 13. Round | 12/01/2022 | Apollon Smyrnis | - | OFI Heraklion | 0:3 | ||||
| 19. Round | 24/01/2022 | Asteras Tripolis | - | Apollon Smyrnis | 1:0 | |
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| 20. Round | 30/01/2022 | PAS Giannina | - | Apollon Smyrnis | 2:0 | ||||
| 21. Round | 02/02/2022 | Apollon Smyrnis | - | PAOK Saloniki | 0:2 | |
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| 22. Round | 06/02/2022 | AEK Athen | - | Apollon Smyrnis | 3:0 | |
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| 26. Round | 06/03/2022 | OFI Heraklion | - | Apollon Smyrnis | 2:0 |
Greece