| 4. Round | 28/08/2021 | SM Caen B | - | US Granvillaise | 1:1 | ||||
| 5. Round | 04/09/2021 | Blois Foot 41 | - | SM Caen B | 2:1 | ||||
| 6. Round | 11/09/2021 | SM Caen B | - | SO Romorantin | 0:0 | ||||
| 8. Round | 25/09/2021 | SM Caen B | - | FC Rouen 1899 | 2:5 | ||||
| 9. Round | 09/10/2021 | EA Guingamp B | - | SM Caen B | 1:1 |  |
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| 10. Round | 23/10/2021 | SM Caen B | - | AS Vitré | 1:0 | ||||
| 12. Round | 20/11/2021 | SM Caen B | - | FC Versailles | 1:0 |  |
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| 14. Round | 11/12/2021 | SM Caen B | - | US Saint-Malo | 0:0 | ||||
| 17. Round | 05/02/2022 | SM Caen B | - | St-Pryvé St-Hilaire | 1:4 | ||||
| 18. Round | 12/02/2022 | US Granvillaise | - | SM Caen B | 1:1 | ||||
| 19. Round | 19/02/2022 | SM Caen B | - | Blois Foot 41 | 3:2 | ||||
| 20. Round | 05/03/2022 | SO Romorantin | - | SM Caen B | 0:1 | ||||
| 21. Round | 12/03/2022 | SM Caen B | - | FC Lorient B | 1:3 | ||||
| 23. Round | 26/03/2022 | SM Caen B | - | EA Guingamp B | 0:2 | ||||
| 24. Round | 09/04/2022 | AS Vitré | - | SM Caen B | 2:0 | |
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| 27. Round | 30/04/2022 | SM Caen B | - | C'Chartres Football | 3:0 |
France