| 1. Round | 15/02/2022 | Santa Cruz | - | Deportes Temuco | 1:1 | ||||
| 2. Round | 21/02/2022 | Deportes Temuco | - | Santiago Wanderers | 1:0 |  |
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| 3. Round | 27/02/2022 | Deportes Iquique | - | Deportes Temuco | 1:0 | ||||
| 5. Round | 14/03/2022 | Deportes Temuco | - | Fernández Vial | 1:1 | ||||
| 6. Round | 22/03/2022 | Puerto Montt | - | Deportes Temuco | 3:0 | ||||
| 7. Round | 05/04/2022 | Deportes Temuco | - | Santiago Morning | 2:1 | ||||
| 8. Round | 12/04/2022 | Rangers | - | Deportes Temuco | 3:2 | ||||
| 9. Round | 16/04/2022 | Deportes Temuco | - | CD Magallanes | 2:4 |
Chile