| 2. Round | 19/04/2021 | Santiago Morning | - | CD Magallanes | 1:2 | ||||
| 3. Round | 26/04/2021 | Coquimbo Unido | - | CD Magallanes | 1:1 | ||||
| 5. Round | 10/05/2021 | Puerto Montt | - | CD Magallanes | 1:1 |  |
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| 6. Round | 18/05/2021 | CD Magallanes | - | Rangers | 0:1 | |
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| 7. Round | 23/05/2021 | Deportes Iquique | - | CD Magallanes | 1:1 | ||||
| 8. Round | 30/05/2021 | Barnechea | - | CD Magallanes | 0:1 | ||||
| 9. Round | 07/06/2021 | CD Magallanes | - | Cobreloa | 2:2 | |
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| 11. Round | 15/07/2021 | CD Magallanes | - | Fernández Vial | 2:1 | ||||
| 12. Round | 21/07/2021 | Santa Cruz | - | CD Magallanes | 2:0 | ||||
| 10. Round | 28/07/2021 | Universidad de Concepción | - | CD Magallanes | 1:1 | ||||
| 13. Round | 02/08/2021 | CD Magallanes | - | Deportes Copiapó | 3:0 | ||||
| 14. Round | 10/08/2021 | San Luis | - | CD Magallanes | 1:1 | ||||
| 15. Round | 16/08/2021 | CD Magallanes | - | Unión San Felipe | 2:1 | ||||
| 16. Round | 22/08/2021 | San Marcos | - | CD Magallanes | 1:2 | |
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| 17. Round | 27/08/2021 | CD Magallanes | - | Santiago Morning | 0:1 | ||||
| 27. Round | 23/10/2021 | CD Magallanes | - | Santa Cruz | 1:1 | |
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| 28. Round | 30/10/2021 | Deportes Copiapó | - | CD Magallanes | 1:1 | ||||
| 30. Round | 13/11/2021 | Unión San Felipe | - | CD Magallanes | 0:0 |
Chile