1. Round | 05/02/2021 | Guaraní | - | Club Nacional | 2:2 | ||||
6. Round | 06/03/2021 | Club Nacional | - | Cerro Porteño | 2:0 | ||||
7. Round | 10/03/2021 | Club Olimpia | - | Club Nacional | 1:4 | ||||
9. Round | 20/03/2021 | Club Nacional | - | 12 de Octubre de Itauguá | 1:1 | ||||
10. Round | 02/04/2021 | Club Nacional | - | Guaraní | 2:0 | ||||
11. Round | 10/04/2021 | Sol de América | - | Club Nacional | 1:2 | ||||
12. Round | 17/04/2021 | Club Nacional | - | Sportivo Luqueño | 1:0 | ||||
13. Round | 26/04/2021 | Libertad | - | Club Nacional | 1:1 | ||||
16. Round | 17/05/2021 | Club Nacional | - | Club Olimpia | 2:1 | ||||
17. Round | 24/05/2021 | Club Nacional | - | River Plate | 0:1 | ||||
18. Round | 31/05/2021 | 12 de Octubre de Itauguá | - | Club Nacional | 2:2 |