| 3. Round | 18/02/2018 | Defensor Sporting | - | Torque | 2:1 |  |
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| 4. Round | 24/02/2018 | Rampla Juniors | - | Defensor Sporting | 1:1 | ||||
| 5. Round | 04/03/2018 | Defensor Sporting | - | Fénix | 3:2 | ||||
| 8. Round | 24/03/2018 | Defensor Sporting | - | CA Cerro | 2:1 |  |
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| 12. Round | 13/04/2018 | Defensor Sporting | - | Liverpool | 1:0 | ||||
| 15. Round | 05/05/2018 | Peñarol | - | Defensor Sporting | 4:1 |
Uruguay